data wrangler
1800 stories
·
38 followers

By Your Childhood Pet Rock in "Omicron" on MeFi

1 Share
It's less that it is a misconception based on poor communication and/or understanding and more that circumstances changed and people have a hard time with that. The neutralizing antibodies the vaccine stimulates your body to produce are less effective against Delta than they were against the original strain.

One of the reasons that boosters with the same vaccine work so well at regaining efficacy with new strains is not just because they prime the immune system into a ready state, but because while you're exposed to an antigen the dendritic cells are constantly presenting said antigens to new B-cells inside your lymphatic system. Those B-cells all have random antibodies and even where those antibodies are effective against the same antigen they're going to have slightly different structures which are all going to have different levels of affinity even to altered antigens.

Our adaptive immune system is not a perfect surgical strike. It's a carpet bomb which basically tries to place bets on every number on the roulette wheel. The more time an antigen is presented, the higher the chance you have of generating an antibody which overwhelms the virus. Nobody takes "perfect is the enemy of the good" more seriously than our immune systems. The immune system will go for mass amounts of "good" every time. One antibody that's good for one antigen may also be perfect for a slightly different one which is why your body keeps a lot of them around.

Look at a live vaccine like MMR. It's a live attenuated vaccine and it does actually live inside our body for the duration of our lives although we're not sure where. You only need one working shot to confer lifelong immunity because the attenuated virus keeps reproducing and getting presented in the lymphatic system to your new B-cells your entire life. They keep creating new antibodies throughout your entire life and the sheer overwhelming number of antibodies your body has on file against a measles/mumps/rubella antigen keeps you basically invincible from them. The only reason we do two shots is just in case something was wrong with the first shot and so we don't have to mass test for follow-up immunity.

mRNA on the other hand is short lived inside the body. Its half-life is about 10 hours before it basically shatters back into its constituent bases inside our cells' cytoplasm. Once that mRNA is gone that's all your body is going to produce of the spike protein. Once all the spike proteins have been produced, taken up, and presented, your B-cells aren't going to get any more exposure or training. A booster kicks that all up into high gear all over again and your antibody selection gets even broader. With a broader selection of antibodies available, the chance that you harbor antibodies with a high enough affinity to the next SARS-CoV-2 antigen in the wild, whatever the variant, goes up.

All infection stuff is about probability and dice rolls which messes with our idiot monkey brains that crave certainty. Keeping yourself safe from infection you can basically reduce the number of dice rolls, you can increase the number of dice you roll in defense, and you can increase the amount of numbers that can cause you to win instead of lose. Boosters do the latter two in spades.
Read the whole story
digdoug
5 hours ago
reply
Louisville, KY
Share this story
Delete

Townscaper demo

1 Comment
a free web demo of Oskar Stålberg's lovely townbuilder #
Read the whole story
digdoug
8 hours ago
reply
Buy this already. Oskar deserves a few bucks!
Louisville, KY
Share this story
Delete

Cleared

1 Comment


(via reddit)
Read the whole story
digdoug
5 days ago
reply
Wait.. that seems like it's just a separate, also serious, crime
Louisville, KY
WorldMaker
3 days ago
Yeah, but they’d have to call in the ZVU for that. [Zoo Victims Unit]
Share this story
Delete

It’s a trap! Wait...that’s a different movie. (But it’s still a trap.)

1 Share

Ah, that sweet spot between Cosplay and LEGO creativity. Brent Waller has built the perfect 1:1 scale Ghostbusters trap – and it looks just amazing! All details from the movie prop have been accurately recreated, including the various knobs, switches, and even opening trap doors. Side by side with the actual thing, you’d have to look twice to be sure you didn’t end up facing Slimer with a ABS plastic replica.

LEGO Ghostbusters Trap

It incorporates a few “Non-purist” elements, like tape for the warning stripes…and LED lights for when the trap is sprung. Yes, this is far more than just a static prop. You’re in for a treat, as Brent has documented all the secrets in a great video!

Better still, this is just the first of a series of 1:1 props Brent will be unveiling, so keep an eye on his channel for more! In the meantime, though, be sure to stroll through our archive of Ghostbusters creations to keep your appetite whetted!

The post It’s a trap! Wait...that’s a different movie. (But it’s still a trap.) appeared first on The Brothers Brick.

Read the whole story
digdoug
19 days ago
reply
Louisville, KY
Share this story
Delete

PowerSquid

1 Comment

The PowerSquid lets you connect multiple devices, even with big power converters, to a single outlet.

-- Zimran Ahmed

[This is a Cool Tools Favorite from 2006]

PowerSquid

Read the whole story
digdoug
19 days ago
reply
These things are magical. Highly recommended.
Louisville, KY
deezil
18 days ago
I have several. Co-sign.
Share this story
Delete

Quote of the Day

2 Shares

However conservatism might be defined, placing the free market at its centre has been self-defeating. Margaret Thatcher’s political outlook was a blend of Burkean traditionalism with Hayekian libertarianism, a highly combustible mix. Unleashing the anarchic energy of free markets dissolves any social order that is based on traditional notions of duty and responsibility. Choice trumps other values, and everything is for sale. The result has been a culture of narcissism and the commodification of anti-capitalism. It is probably only an oversight on the part of their PR team that the Kardashians have not been marketed as daily readers of Karl Marx.

  • John Gray, writing in this week’s New Statesman
Read the whole story
digdoug
20 days ago
reply
Louisville, KY
Share this story
Delete
Next Page of Stories